There’s a moment in every skin consultation where I can see the lightbulb go off. A patient will tell me they’ve tried everything: serums, peels, lasers, even filler. Their skin looks fine, but it doesn’t look alive. It doesn’t bounce back the way it used to. It just feels… tired.

That’s usually when I bring up Rejuran.

What Rejuran Actually Does

Most treatments work on the surface or add volume underneath. Rejuran is different. It’s a polynucleotide (PN) treatment derived from salmon DNA that signals your skin cells to repair themselves. Think of it less like a product and more like a message your skin receives: hey, start healing.

The polynucleotides in Rejuran stimulate fibroblasts, the cells responsible for producing collagen and elastin. Unlike treatments that rely purely on a wound-healing response, Rejuran works at the cellular communication level. It’s regenerative, not just reactive. I deliver it through microinfusion, which means your skin gets the benefit of both the polynucleotides and the microchanneling process.

For my patients here in Tempe, that distinction matters. Living in the desert means our skin is under constant stress from UV exposure, low humidity, and heat. Rejuran doesn’t just treat the symptoms of that damage. It helps your skin get better at repairing itself.

Who It’s For

I recommend Rejuran for patients who:

  • Have fine lines that aren’t deep enough for filler but won’t go away with skincare
  • Notice their skin texture has changed (rougher, duller, less elastic)
  • Want to improve acne scarring without aggressive downtime
  • Are looking for something that works with their skin rather than overriding it

It’s also a fantastic option for patients in their 30s and 40s who want to stay ahead of aging without jumping straight to injectables. I see a lot of professionals in the Tempe and Scottsdale area who want results that look completely natural, and Rejuran delivers exactly that.

What the Treatment Looks Like

The procedure itself is straightforward. I apply the Rejuran topically and use microinfusion with a hydraneedle to deliver it into the skin across the treatment area, usually the full face, though some patients focus on under-eyes or specific zones. The whole thing takes about 30 minutes.

Most patients describe the sensation as mild. We apply topical numbing beforehand, so it’s very manageable. You might see some light redness afterward, but that typically resolves by the next morning.

I tell my patients to plan for minimal downtime. You can go back to work the same day. Just skip heavy makeup for 12 hours and avoid direct sun for a couple of days (which, in Arizona, means being strategic about your morning walk).

When You’ll See Results

This is where patience comes in. Rejuran isn’t a one-and-done treatment. The healing process is gradual because your skin is literally rebuilding from within.

Most patients notice improved texture and hydration within two to three weeks after their first session. The real transformation happens after a series of three treatments, spaced about four weeks apart. By the end of that series, patients consistently tell me their skin looks healthier than it has in years. Not different. Not “done.” Just genuinely better.

Maintenance is easy: one session every four to six months keeps things going.

How It Fits With Other Treatments

One thing I love about Rejuran is how well it plays with other treatments. I often combine it with Botox for patients who want both movement correction and skin quality improvement. It also pairs beautifully with microneedling or a VI Peel for patients dealing with texture and tone issues.

Think of Rejuran as the foundation. It makes everything else work better because your skin is healthier at a cellular level.

Why I’m Excited About It

I’ve been an aesthetic nurse for over a decade, and treatments like Rejuran are why I still get excited about this field. It’s not about adding something artificial. It’s about giving your skin what it needs to do what it already knows how to do.

If you’re in Tempe or the Phoenix area and you’ve been feeling like your skin needs something but you’re not sure what, Rejuran might be the answer you didn’t know existed. Come talk to me about it. I’d love to show you what’s possible when your skin starts healing from within.